Interactions between platelet-surface glycoproteins. Identification of glycoproteins capable of binding to platelet surfaces
نویسندگان
چکیده
منابع مشابه
Quantitative Immunophemotyping of Platelet Surface Glycoproteins among Iranian Patients with Bernard-Soulier Syndrome
Background: Bernard-Soulier syndrome is a rare inherited bleeding disease caused by quantitative or qualitative defect of GPIb/IX/V, a platelet complex that binds the Von Willebrand factor. The expression of GPIb-IX-V complex can be evaluated by flow cytometry and confirmed by the absence of ristocetin-induced platelet aggregation in platelet-rich plasma. The main aim of the present study was t...
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Glycoproteins I Ib / I I Ia form a Ca2+-dependent complex that functions as the fibrinogen receptor on human platelets (1). Several reports have indicated that this fibrinogen receptor is also expressed on the surface of human monocytes (2-4). Of three monoclonal antibodies directed against platelet I Ib/ I I Ia , two were reported to give a positive reaction with monocytes as well (4). Other i...
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We have measured the association of platelet surface membrane proteins with Triton X-100 (Triton)-insoluble residues in platelets surface labeled with 125I. In both concanavalin A (Con A)-stimulated and resting platelets, this fraction is composed largely of polypeptides with apparent molecular weights of 45,000, 200,000, and 250,000 which comigrate with authentic actin, myosin heavy chain, and...
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The function of blood platelets to prevent blood loss at injured sites in the vasculature depends largely on their capacity to adhere, aggregate, promote coagulation and secrete factors that induce vasoconstriction and recruit inflammatory cells. Produced in large numbers from megakaryocytes, platelets enter the circulation for 7–10 days primed to fulfill their hemostatic function. By 1970, tho...
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labeled membrane proteins by density gradient ultracentrifugation using 1 O%-40% sucrose gradients containing the nonionic detergent. Studies were performed using soluble proteins derived from membranes isolated in the presence or absence of EDTA. Analysis of gradient fractions by SDS-polyacrylamide gel electrophoresis showed that in the absence of divalent cation chelation. GP lIb and lIla pen...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0264-6021
DOI: 10.1042/bj2020707